The HPA Axis: Your Body’s Stress Symphony (and How to Keep It in Harmony) By Carli Kilgore
When we talk about stress, adrenal fatigue, burnout, or even hormonal imbalances, there’s one key system at the center of it all: the HPA Axis. Think of it as your body’s stress conductor—quietly orchestrating how you respond to the world around you, minute by minute, day by day.
But what is the HPA axis exactly, and why does it matter so much for your health and healing?
Let’s dive in.
💡 What is the HPA Axis?
The HPA axis stands for the Hypothalamic-Pituitary-Adrenal axis. It's a dynamic communication network between three major glands:
Hypothalamus (in the brain) – The control center, sensing changes and sending out the first signal.
Pituitary gland (also in the brain) – The messenger, receiving signals from the hypothalamus and directing the adrenal glands.
Adrenal glands (on top of the kidneys) – The doers, releasing cortisol and other stress hormones in response to the signals they receive.
This trio works together to manage your stress response, regulate energy, influence your immune system, control blood pressure, and even affect digestion and mood.
🧠 Stress & the HPA Axis: A Delicate Balance
Your HPA axis is beautifully designed to help you survive a threat—a lion chasing you, a car cutting you off, or a big work presentation. In short bursts, cortisol (your primary stress hormone) is adaptive. It sharpens your mind, raises your blood sugar, and readies your muscles.
But here’s the catch…
Chronic, unrelenting stress—from deadlines, poor sleep, toxic relationships, blood sugar dips, overtraining, or even inflammation—keeps this system "on" all the time. That’s when problems start.
🛑 What Happens When the HPA Axis Goes Off Track?
When your HPA axis is chronically activated, it starts to misfire. Over time, this can lead to what's often called HPA axis dysregulation (formerly known as adrenal fatigue). It’s not that your adrenals are “tired,” but rather the entire communication loop is off.
Symptoms can include:
Fatigue (especially in the morning or mid-afternoon)
Difficulty sleeping (wired but tired at night)
Cravings for salt, sugar, or caffeine
Anxiety or feeling "on edge"
Brain fog and poor memory
Low libido
Hormonal imbalances (e.g., PMS, irregular periods, low testosterone)
Immune dysfunction (frequent colds or autoimmunity)
Sound familiar?
🔍 Getting to the Root: What’s Driving Your HPA Dysregulation?
As a root cause practitioner, we don’t just look at symptoms—we ask why. What’s behind the HPA imbalance?
Here are common contributors:
Emotional stress – trauma, grief, work overload, perfectionism
Inflammation – gut issues, infections, toxins, food sensitivities
Blood sugar imbalances – skipping meals, sugar highs and crashes
Poor sleep quality – not just hours, but restorative sleep
Circadian rhythm disruption – blue light at night, shift work, irregular schedules
Overtraining or under-recovery – especially in women and high achievers
🛠 How to Rewire and Support Your HPA Axis (Naturally)
Healing the HPA axis is not about popping an adaptogen and hoping for the best. It's about creating safety in the body, consistency in your rhythms, and reconnection with your body’s needs.
Here’s where we start:
1. Nourish Regularly & Stabilize Blood Sugar
Eat balanced meals with protein, fat, and fiber
Ditch intermittent fasting if you're burnt out—it’s not for everyone
Keep snacks handy (especially if you crash mid-morning or mid-afternoon)
2. Prioritize Deep, Restorative Sleep
Get morning sunlight to anchor your circadian rhythm
Shut down screens an hour before bed
Consider magnesium, glycine, or calming herbs (under guidance)
3. Embrace Nervous System Regulation
Breathwork, meditation, somatic practices, EFT, or yoga
Even 10 minutes a day can shift your state from “fight or flight” to “rest and repair”
4. Honor Your Energy Cycles
Match your workouts to your energy (hint: not every day needs to be high-intensity)
Build in true rest days—guilt-free
5. Use Targeted Supplementation (When Needed)
Adaptogens like ashwagandha, rhodiola, holy basil
Nutrients like B vitamins, vitamin C, magnesium, and electrolytes
Functional testing to tailor support (e.g., DUTCH test, salivary cortisol)
❤️ Final Thoughts: Your Body Wants to Heal
The HPA axis isn’t broken—it’s adaptive. It’s doing its best to protect you based on the signals it’s receiving. When you begin to shift those inputs—physically, emotionally, environmentally—you help your body feel safe again.
And from that place of safety, healing becomes not just possible—but inevitable.
Ready to rebalance your HPA axis and reclaim your energy?
Let’s work together to get to the root and build resilience from the inside out.
Want to learn more about Stress Reset?
Watch this podcast on Youtube about
The Stress Reset Protocol: How to Calm Your Brain & Body for Good
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